Medicine Guideline of Dalteparin Sodium Fragmin SC 7500 IU Injection

Dalteparin Sodium Fragmin SC 7500 IU Injection is a moo atomic weight heparin utilized for the prophylaxis of thrombotic occasions in certain patients and anticipates intense cardiac ischemic occasions in patients with unsteady angina and non-Q-wave myocardial infarction.

An anticoagulant medicine or “blood more slender” utilized to avoid genuine blood clots or heart complications due to blocked blood stream in certain patients who are at tall risk.

Dalteparin Sodium Fragmin SC 7500 IU Injection is an antithrombotic specialist, which acts primarily through its capacity to potentiate the hindrance of figure Xa and thrombin by antithrombin. It has a generally higher capacity to potentiate calculate Xa restraint than to drag out aPTT.

Use of Dalteparin Sodium Fragmin SC 7500 IU Infusion

Dalteparin Sodium Fragmin SC 7500 IU Injection is utilized as a prophylaxis for deep-vein thrombosis and pneumonic embolisms in patients experiencing common surgery (e.g., stomach, gynecologic, urologic), and in patients with intense restorative conditions (e.g. cancer, bed rest, heart disappointment, serious lung illness). It is too utilized in patients who have extremely confined versatility, which postures a hazard for thromboembolic complications.

Dalteparin Sodium Fragmin SC 7500 IU Injection is too utilized concomitantly with headache medicine and/or other treatment (e.g., nitrates, β-adrenergic blockers, clopidogrel, platelet glycoprotein [GP] IIb/IIIa-receptor inhibitors) to diminish the hazard of intense cardiac ischemic occasions. The patients who experience this treatment combination have unsteady angina or non-ST-segment elevation/non-Q-wave myocardial localized necrosis (i.e., non-ST-segment rise intense coronary syndromes).

Side Effects

Elevated serum transaminase levels (AST and ALT), unfavorably susceptible responses (e.g. pruritus, hasty, fever, inj location response, bullous ejection), torment on location. Epidural or spinal haematomas that may result in lasting loss of motion, serious drain, thrombocytopenia.

Dosage & Organization of Dalteparin Sodium Fragmin SC 7500 IU Injection

Intravenous-

Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration: 30-40 U/kg IV inj, at that point 10-15 U/kg/hr as IV infusion.

Subcutaneous-

Venous thromboembolism: 200 U/kg/day as a single or in 2 separated dosages in pregnant and high-risk patients. Max: 18,000 U/day.

Prophylaxis of venous thromboembolism amid surgical methods Direct hazard: 2,500 U given 1-2 hr pre-op at that point 2,500 U once every day for 5-7 days or until the quiet is completely ambulant. Tall hazard: 2,500 U given 1-2 hr some time recently and 8-12 hr after the strategy at that point 5,000 U daily.

Unstable angina: 120 U/kg 12 hourly proceeded for 5-8 days w/ low-dose headache medicine. Max: 10,000 U 12 hourly. 

Overdose 

Symptoms: Haemorrhagic complications.

Management: Regulate protamine sulfate by moderate Dalteparin Sodium Fragmin SC 7500 IU Injection at a dosage of 1 mg for each 100 anti-Xa U of dalteparin Na given.

Indications

Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration, Prophylaxis of clotting in extracorporeal circulation in haemodialysis or haemofiltration, Unsteady angina, Prophylaxis of venous thromboembolism amid surgical methods, Venous thromboembolism.

Interaction

Increased hazard of discharge with other anticoagulant/ antiplatelet operators (e.g. headache medicine/ dipyridamole, glycoprotein IIb/ IIIa receptor opponents, vit K enemies, NSAIDs, cytostatics, dextran, thrombolytics, sulfinpyrazone, probenecid, etacrynic corrosive). Diminished anticoagulant impact with antihistamines, cardiac glycosides, tetracycline and ascorbic corrosive.

Contraindications

Hypersensitivity. Dynamic major dying, extreme coagulation disarranges; lumbar cut; thoughtful piece; brain, spinal line, eye or ear surgery; extreme hypertension

Pregnancy & Lactation

Pregnancy Category B. Either animal-reproduction ponders have not illustrated a fetal hazard but there are no controlled considers in pregnant ladies or animal-reproduction considers have appeared an unfavorable impact (other than a diminish in richness) that was not affirmed in controlled thinks about in ladies in the 1st trimester (and there is no prove of a chance in afterward trimesters).

Precautions 

Patient with expanded hazard of dying complications (e.g. taking after surgery or injury, haemorrhagic stroke, thrombocytopenia or flawed platelet work, uncontrolled HTN, hypertensive or diabetic retinopathy). Expanded chance of spinal or epidural haematomas in quiet experiencing neuraxial anesthesia or spinal cut esp with post-op utilize of indwelling epidural catheters. Hepatic and renal disability. Pregnancy and lactation.